As a consequence, the survival benefit observed in HPV-induced HNSCC may not be the result of HPV positivity per se, but rather the result of the absence of p53 gene mutations or p16INK4A deletion in HPV(+) tumors, which are responsible for poor prognosis in HPV(-) patients [77]. The gene discussed is CDKN2A; the disease is head and neck squamous cell carcinoma.