NOTCH1 and head and neck squamous cell carcinoma: In addition to the mutated genes previously implicated in HNSCC (TP53, CDKN2A, PTEN, PIK3CA, HRAS) [29,30], sequencing revealed mutations in additional genes, namely NOTCH1 [27,28], IRF6 [28], TP63 [28], and FBXW7 [27].