ATP2A3 and acute promyelocytic leukemia: In several independent model systems of differentiation such as retinoic acid-induced differentiation of acute promyelocytic leukemia cells, phorbol ester-induced differentiation of megakaryoblastic cell lines, or short chain fatty acid-induced, as well as spontaneous differentiation of colon carcinoma cells, differentiation, detected by a multitude of established markers, is accompanied by a marked induction of SERCA3 protein expression, whereas the expression of the simultaneously expressed SERCA2 isoenzyme is much less modified, or is in fact often decreased.