PDLIM7 and infection: Importantly, the modulation of SERCA expression by EBV was observed only in cell lines infected with a fully immortalizing EBV strain (B95.8 virus), whereas infection with the non-immortalizing P3HR-1 virus strain (in which LMP-1 expression is deficient due to a deletion in the EBNA2 sequence and consequent loss of trans-activation of LMP-1 expression by EBNA2 [111]), SERCA expression was not modified [112].