On the other hand, SERCA3 expression is progressively decreased along the adenoma/adenocarcinoma sequence: in contrast to normal epithelium that strongly expresses SERCA3, staining is globally decreased and heterogeneous in adenomas, with a more marked decrease observed in high grade lesions, is very low in well differentiated adenocarcinomas, and barely detectable or absent in moderately and poorly differentiated carcinomas. The gene discussed is ATP2A3; the disease is carcinoma.