On the other hand, SERCA3 expression is progressively decreased along the adenoma/adenocarcinoma sequence: in contrast to normal epithelium that strongly expresses SERCA3, staining is globally decreased and heterogeneous in adenomas, with a more marked decrease observed in high grade lesions, is very low in well differentiated adenocarcinomas, and barely detectable or absent in moderately and poorly differentiated carcinomas. This evidence concerns the gene ATP2A3 and adenocarcinoma.