Furthermore, the action of 27-OHC on estrogen receptors has been putatively linked with breast cancer: A decrease in the expression of E-cadherin and β-catenin, paralleling the loss of adherens junction complex, was observed in MCF7 breast cancer cells exposed 27-OHC, indicating an epithelial-mesenchymal transition characteristic of tumor development [71]. The gene discussed is ESR1; the disease is breast cancer.