CFH and Dowling-Degos disease 1: Factor H gene mutations and polymorphisms, as well as anti-factor H autoantibodies, are associated with several diseases that are characterized by complement dysregulation, e.g., the eye disorder age-related macular degeneration (AMD) and the rare kidney diseases atypical hemolytic uremic syndrome (aHUS) and dense deposit disease (DDD) [6,7,8].