Finally, we have previously shown that a single immunizing dose of a recombinant adenovirus (rAd) expressing a circumsporozoite (CS) antigen of Plasmodium yoelii, AdPyCS, induced a robust PyCS-specific CD8+ T cell response; moreover, a strong protective anti-malaria immunity, which is mediated by CD8+ T cells [5]. This evidence concerns the gene ALDH18A1 and malaria.