Otherwise known as melanoma-associated chondroitin sulphate proteoglycan (MCSP) or human high molecular weight-melanoma associated antigen (HMW-MAA), CSPG4 is a 2322-residue membrane-bound protein overexpressed on 80–85% of melanoma lesions and also on a proportion of basal cell and breast carcinomas and several leukaemia types (33,34). Here, CSPG4 is linked to leukemia.