CSPG4 is known to play roles in the adhesion, spreading and migration of melanoma cells through activation of intracellular signalling cascades such as the focal adhesion kinase (FAK), PI3K/AKT, NFκB and MAPK/ERK 1/2 pathways, promoting sustained high levels of activatory signals required for malignant progression (35–37). This evidence concerns the gene CSPG4 and melanoma.