Melanoma tumours feature increased production of pro-angiogenic factors such as the VEGF family molecules, VEGF-A involved in angiogenesis, VEGF-B associated with embryonic angiogenesis, VEGF-C with known roles in lymphangiogenesis, VEGF-D participating in lung bronchiole lymphatic vasculature, and VEGF-E encoded from a gene of viral origin with endothelial cell proliferative properties. The gene discussed is VEGFA; the disease is melanoma.