NFKB1 and cancer: In addition, proteasome inhibition also augments the cancer cell response to chemotherapy and radiation by modulating other NF-κB related proteasome-dependent regulatory proteins involved in treatment resistance such as Bcl2, p53, the caspases and stress response molecules like SAPK/JNK, as well as accumulation of misfolded proteins and anti-angiogenic effects (10,13).