As shown in our results, treatment of SW620 cells with CFZ and CPT-11 resulted in the activation of caspase 3 and CD95-dependent apoptotic pathways, as well as of proteins associated with pro-apoptotic effects; this included p-p38 and ATF3 which have been shown to play an important regulatory role in the apoptosis of tumor cells (42). The gene discussed is ATF3; the disease is neoplasm.