Although it is known that MTHFR TT might be a risk biomarker against longevity from other perspectives, we cannot exclude the possibility that it may also be in favor of good health or long life span as implicated by Le Marchand et al. that there might be an inverse association between MTHFR 677TT genotype and the development of colorectal cancer[41]. This evidence concerns the gene MTHFR and colorectal cancer.