Mechanistic possibilities depicted include: (i) contribution of resveratrol in control of PI3K/AKT signaling in cancer cells in vitro and possibly in vivo; (ii) role of NQO2 in the control of AKT activation (Fig. 5A) and additional modulation of this control by resveratrol (Fig. 5B); and (iii) whether NQO2 might function as a tumor suppressor in PTEN-deficient cancer cells by the novel NQO2-non-kinase-mediated PI3K/AKT survival pathway. The gene discussed is PTEN; the disease is cancer.