Hyperactivity of the renin-angiotensin system (RAS), resulting in elevated concentrations of its principal effector peptide, angiotensin (Ang) II, plays a key role in activating pathways leading to increased vascular inflammation, oxidative stress, endothelial dysfunction and tissue remodeling in variety of conditions, including diabetes and its associated complications [5], [6]. Here, REN is linked to diabetes mellitus.