In addition to significant differences in glucose metabolism parameters (FPG, HbA1c, FPI, HOMA-IR) between T2D patients and controls, diagnosis of T2D was associated with significantly higher serum concentrations of ANGPTL6, Nampt, omentin, progranulin, as well as lower circulating DLK1 (Table 1). This evidence concerns the gene ITLN1 and type 2 diabetes mellitus.