Moreover, global analysis of copy-number alterations (CNAs) in PCa has reported dramatic amplifications of oncogenes, such as MYC (on 8q24.21) and AR (Xq12), deletions of tumor suppressor genes, such as PTEN (10q23.31), RB1 (13q14.2), TP53 (17p31.1) and CDKN1B (due to the broader deletion of the 12p13.31-p12.3 genomic region), and interstitial 21q22.2–3 deletion spanning ERG and TMPRSS2 [87]. Here, RB1 is linked to posterior cortical atrophy.