MYC and cancer: It is important to note that these three miRNAs have been hypothesized to possess tumor suppressor roles: miR-24 has recently been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc [58], low levels of miR-29a have been attributed to the methylation of its promoter region in PCa [59], and miR-145 is hypothesized to play roles in several types of cancer [60].