Interestingly, the findings depicted in Figures 8 & 9 characterize miR-24, miR-29a, and miR-145, which are identified by IntegraMiR to be significantly downregulated, as inhibitors of the PI3K/AKT, RAS/RAF/ERK and RB signaling pathways through specific FFLs and Type III loops, as depicted in Figure 11, and suggest tumor suppressor roles for these miRNAs, coordinately cooperating with the tumor suppressors PTEN, CDKN1B (p27) and RB1 (Rb). This evidence concerns the gene RB1 and neoplasm.