For example, Aebp2, an epigenetic DNA-binding protein involved in Hirschsprung's disease and Waardenburg syndrome [31], and Kcnj16, a potassium channel involved in respiratory response to hypoxia during breathing [32], showed VPA-restored expression changes, but the p value was greater than 0.05. Here, KCNA3 is linked to Hirschsprung disease.