SPRY4 and non-small cell lung carcinoma: Although only a small number of functional lncRNAs have been well characterized to date, they have been shown to regulate gene expression at various levels, including chromatin modification, transcription, and post-transcriptional processing.33, 34, 35 Here, the possible mechanisms that underlie such regulatory behaviors still remain to be fully understood despite our observation of SPRY4-IT1-induced NSCLC cell growth arrest and regulation of the EMT phenotype.