SPRY4-IT1 expression levels in NSCLC significantly correlated with tumor size (P=0.001), advanced pathological stage (P<0.001), and lymph node metastasis (P=0.003), but were not associated with other parameters such as gender (P=0.298) or age (P=0.522) in NSCLC (Supplementary Table 1). This evidence concerns the gene SPRY4 and metastatic malignant neoplasm in the lymph nodes.