SPRY4 and cancer: It has an essential role in the epigenetic maintenance of the H3K27me3 repressive chromatin mark.18 Overexpression of EZH2 has been widely reported in many cancers, including NSCLC.16, 19, 20 In the present study, we demonstrated that the lncRNA SPRY4 intronic transcript 1 (SPRY4-IT1), derived from an intron within SPRY4, is transcriptionally repressed by EZH2.