SPRY4 and melanoma: SPRY4-IT1 was previously reported to be upregulated in melanoma cells, and knockdown of its expression led to cell growth arrest, invasion inhibition, and elevated rates of apoptosis.21 Moreover, aberrant expression of SPRY4-IT1 was also found to contribute to the abnormal condition of trophoblast cells HTR-8/Svneo.22 In this study, we explored the expression pattern of SPRY4-IT1 in NSCLC tissues and cell lines, and investigated the effects of SPRY4-IT1 expression on NSCLC cell phenotypes both in vitro and in vivo.