Investigating the molecular network regulated by Suf/Spastizin in zebrafish oocytes as well as transferring these results to the nervous system as described for Atlastin (SPG3A) in zebrafish [42] and Drosophila[107] could provide novel insights into the biochemical etiology of HSP and bring us closer to a therapeutic treatment for patients. Here, ZFYVE26 is linked to hereditary spastic paraplegia.