Among seropositive RA patients, the variant alleles of TLR4 rs12377632 (OR = 0.63, p = 0.042, q = 0.61) and IL17A rs2275913 (OR = 1.63, p = 0.030, q = 0.61) were significantly associated with ACR50 response. This evidence concerns the gene TLR4 and rheumatoid arthritis.