Additionally, significant associations with ACR50 outcome (Table 3, Table S3a-c) were found for variant allele carriers of TLR4 rs5030728 (OR = 1.51, p = 0.033, q = 0.82) and for carriers of the homozygote variant genotype of IL1B rs1143623 (OR = 2.14, p = 0.037, q = 0.90) among all RA patients. The gene discussed is TLR4; the disease is rheumatoid arthritis.