The role of miR-146a in regulating NF-κB activation was consistent with the observed defect in downregulation of NF-κB-dependent cytokines and chemokines IL-1β, IL-6, Cxcl1 and Cxcl2, in B6 miR-146a−/− mice at 4 weeks post-infection (Figure 4). Here, IL1B is linked to infection.