It is important to note that uninfected B6 miR-146a−/− mice did not exhibit any abnormalities in expression of these genes, indicating that this hyperactivity is due to a failure to down-regulate the NF-κB response after infection, rather than general NF-κB hyperactivity, as is observed in aging B6 miR-146a−/− mice [30]. The gene discussed is NFKB1; the disease is infection.