This is in contrast to arthritis-susceptible B6 IL10−/− mice, where previously published data show that in addition to upregulation in IL-1β, IL-6, Cxcl1 and Cxcl2, IFNγ and Cxcl10 are upregulated 16-fold and 141-fold at 2 weeks, and 22-fold and 189-fold at 4 weeks, respectively [47]. Here, IL1B is linked to arthritic joint disease.