Given the ability of BIX02694 to act as a GPBAR1 agonist to reduce monocyte activation in vitro and proinflammatory cytokine production in vivo, we tested whether this GPBAR1-mediated effect on monocyte activation is sufficient to impact an autoimmune disease in a more chronic setting, as it may have therapeutic implications for human diseases. The gene discussed is GPBAR1; the disease is autoimmune disease.