We identified 17 potentially ARVC associated genetic variants in 19 of 30 index cases (63%) after screening the ARVC-related desmosome genes (figure 1A): 43% in PKP2, 10% in DSC2, 6.5% in DSP and 3.5% in DSG2. We did not find any mutation neither in JUP nor TMEME43. Eighteen patients carried the heterozygote mutations, while only one individual carried the variation (DSG2 c.2440T>C, p.C814R) in homozygosity. The gene discussed is PKP2; the disease is arrhythmogenic right ventricular cardiomyopathy.