ARVC is mainly caused by pathogenic mutations in genes encoding desmosomal proteins: plakophilin-2 (PKP2), desmoplakin (DSP), desmocolin-2 (DSC2), desmoglein-2 (DSG2) and plakoglobin (PG), encoded by the JUP gene. This evidence concerns the gene JUP and arrhythmogenic right ventricular cardiomyopathy.