In addition, three independent large scale sequencing studies on human breast cancers discovered recurrent RUNX1 mutations and deletions in human tumours [14]–[16] while Kadota et al showed by qRT-PCR on a small breast cancer cohort (29 samples) that RUNX1 downregulation is associated with high-grade primary breast tumours [17]. This evidence concerns the gene RUNX1 and breast cancer.