CASP3 and early-onset autosomal dominant Alzheimer disease: Since caspase-3 activity appears to contribute to synaptic LTD in the rat hippocampus [17], [18] and to early synaptic dysfunction in mouse models of Alzheimer's disease [20], further studies of age-related increases in caspase activity and its role in Drosophila neuronal excitability and cell death are warranted.