Strandberg et al. using a Staphylococcus aureus (S. aureus) model of sepsis reported that mice fed high fat diet had greater incidence of mortality, renal bacterial load, unstable innate immune system (increased serum interleukin-1 receptor antagonist (IL-1Ra), IL-10, and IL-1β), and granulocyte dysfunction [11]. The gene discussed is IL1B; the disease is Sepsis.