Among them, dinaciclib (a cyclin-dependent kinase (CDK) inhibitor), ONO-4059 (a Bruton's tyrosine-kinase (BTK) inhibitor), ABT-199 (a Bcl-2 inhibitor), and overall ibrutinib (another BTK inhibitor) have demonstrated a significant activity in CLL [72–75]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.