FAT1 and obesity disorder: The n-3 PUFAs have been documented to exert anti-inflammatory effects in the context of obesity by modulating adipose tissue, skeletal muscle, and hepatic function [116]. In vitro, EPA stimulates glucose and fatty acid uptake in skeletal muscle cells by increasing expression of the transporters GLUT1 and CD36/FAT (fatty acid translocase) and increasing glucose oxidation [117].