For instance Panebianco et al. [90] in a recent study showed that MRSI followup, using CC/C ratio, shows a greater potential compared to PSA in monitoring patients after EBRT because MRSI can demonstrate PCa recurrence or residual disease before the BR occurs, leading to the possibility to deliver salvage local therapy, and thus the chance for cure as early as possible. The gene discussed is KLK3; the disease is posterior cortical atrophy.