Because low-grade and chronic inflammation and impaired lipid metabolism contribute to NAFLD, we analyzed the effects of DHA and lysine on the expression of hepatic proinflammatory genes, including tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), monocyte chemotactic protein-1 (MCP1), and interleukin-6 (IL-6) and lipogenic genes, including acetyl-CoA carboxylase1 (ACC1), sterol regulatory element-binding protein 1c (SREBP-1c), and fatty acid synthase (FAS). This evidence concerns the gene ACACA and metabolic dysfunction-associated steatotic liver disease.