CA12 and cancer: To investigate the reactivities of the MAbs with the cellular full-length CA XII, we have used human cancer cell lines A-498 (human kidney carcinoma), U-87 (human primary glioblastoma), A-549 (human lung adenocarcinoma), HeLa (human cervical carcinoma), and CaSki (human cervical carcinoma) with previously reported different expression levels of CA XII [13, 20].