IL18 and acute kidney injury: The cut-off value of urinary IL-18 that differentiates between patients with AKI and those with other causes of renal impairment was 1119.6 μg/g creatinine (area under ROC curve is 0.975) (sensitivity 95.5% and specificity 91.3%) with PPV of 84 and NPV of 99.3 (Figure 3).