Since the GPs colocalize with CFTR, future research should be done to determine whether GPs regulation of water and electrolyte transport has any physiological effect on the lung, pancreas, and intestine of CF patients (via GC-C-independent signaling pathways) and could GPs effects on ion transport be used as a new therapy approach in patients with cystic fibrosis. This evidence concerns the gene GUCY2C and cystic fibrosis.