Other members of GC-C signaling pathways of GPs (GC-C, PKG II, CFTR, and anion exchanger Slc4a2) are located at the apical membrane of the same cells suggesting physiological role of GN in production of hepatic and cystic bile via regulation of water and electrolyte transport by paracrine signaling pathway [121]. Here, GUCY2C is linked to ganglioneuroma.