REN and endothelial dysfunction: Although the precise mechanism by which arterial blood pressure enhances in HI obese subjects remain to be elucidated, taking in account our and previous findings we may suppose that systemic inflammatory response, endothelial dysfunction, sympathetic neural and renin-angiotensin overactivity and, renal fluid and electrolyte balance disorder is thought to play a dominant role in the long-term salt and water retention, vascular resistance and consequently, enhanced blood pressure.