In addition, it was reported that a synthetic protein can interact with YB-1, stimulating its translocation from the cytoplasm to the nucleus, where YB-1 binds to the promoters of collagen genes and suppresses their transcription, preventing the progression of systemic and hepatic fibrosis (Higashi et al., 2003a,b, 2011; Hasegawa et al., 2009). This evidence concerns the gene YBX1 and Hepatic fibrosis.