CYCS and cancer: tRNAArg(UCU), tRNAArg(CCU), tRNAThr (CGU), tRNASer(CGA), and tRNATyr(GTA) were among the most over-expressed tRNAs, while tRNAHis(GTG), tRNAPhe (GAA), and tRNAMet(CAT) were the least over-expressed tRNAs (Pavon-Eternod et al., 2009) indicating overexpression is not random and may be related to regulation of cytochrome c. Identification of the tRNA sites involved in binding to cytochrome c might help elucidate the connection between tRNA overexpression and cancer.