CXCL12 and coronary artery disorder: Genome-wide association studies of European ancestry revealed 2 single nucleotide polymorphisms (SNPs) on locus 10q11.21, 80 kB downstream of CXCL12, to be significantly associated with CAD and MI (Burton et al., 2007; Samani et al., 2007; Kathiresan et al., 2009; Farouk et al., 2010; Schunkert et al., 2011), although genome-wide significance was not reached in 2 other studies (Ripatti et al., 2010; Peden et al., 2011) (Box 4).