Intracardiac or intramyocardial injection of CXCL12 reduced infarction size and increased cardiac function after MI/IRI (Hu et al., 2007) and MI (Segers et al., 2007; Saxena et al., 2008), and cardioprotective effects were blocked with AMD3100 (Hu et al., 2007). The gene discussed is CXCL12; the disease is myocardial infarction.