In considering the molecular mechanism underlying the accumulation of CCR5 in scleroderma monocytes and its reversal by CSD, it is interesting to note that CCR5 is a G protein-coupled receptor (Oppermann, 2004) and that caveolin-1 is known to bind to and modulate the function of G proteins (Li et al., 1995). Here, CCR5 is linked to scleroderma.