Analogous to our previous studies, we find that SSc monocytes accumulate high levels of CCR5, are hypermigratory toward the CCR5 ligands MIP1α and MIP1β, that the accumulation of CCR5 is inhibited by CSD, and that the hypermigration is totally blocked by CSD (Figure 8). The gene discussed is CCL4; the disease is systemic sclerosis.