However, there are only a limited number of studies examining the involvement of matriptase-2 in human cancer, including breast cancer (Hartikainen et al., 2006; Parr et al., 2007; Tuhkanen et al., 2013) and prostate cancer (Sanders et al., 2008; Webb et al., 2012). The gene discussed is TMPRSS6; the disease is breast cancer.