After adjusting for these variables, hypocretin-1 levels remained significantly and independently associated with AD+MCI-AD, with an OR of 2.70 (95%CI = [1.37–5.32]) for Model 1 and an OR of 2.66 (95%CI = [1.35–5.23]) for Model 2, exceeding that for Aβ42 (Table 3). This evidence concerns the gene HCRT and Alzheimer disease.