Other mutants models like the Creb1DARPP32Cre or Creb1EMX1Cre also exhibit normal anxiety-like behaviors (McPherson et al., 2010; Madsen et al., 2012) but in the Creb1NesCre mice (Valverde et al., 2004) and the α/Δ CREB strain (Pandey et al., 2004; Valverde et al., 2004) enhanced anxiety responses had been reported. This evidence concerns the gene CREB1 and Anxiety.