MAPK8 and hepatitis A virus infection: Because JNK signaling plays a key role in regulating the inflammatory responses [20], to further I/R-induced hepatitis using immunoblotting and immunohistochemistry, I/R and A/R upregulated the levels of p-JNK, and NaHS preconditioning downregulated JNK1 and ERK phosphorylation compared with that in the I/R and A/R groups, whereas p-ERK remained at baseline levels in the nonpretreated animals (control and I/R injury) (Figures 8(a) and 8(c)).