Neuroinflammation and excitotoxicity have key roles as triggers and sustainers of the neurodegenerative process and thus, elevated levels of TNF-α have been found in traumatic brain injury [16], ischemia [17, 18], Alzheimer's disease (AD) [19, 20], Parkinson's disease (PD) [21, 22], multiple sclerosis (MS) [23, 24], and amyotrophic lateral sclerosis (ALS) [25, 26]. The gene discussed is TNF; the disease is amyotrophic lateral sclerosis.