Therefore, the aim of this study was to assess whether OSAHS is associated with activation of the inflammatory cytokine system in patients with ED compared to patients with OSAHS and normal sexual function, evaluating a wide range of inflammatory (hsCRP, IL-6, IL-8, and TNF-a) and anti-inflammatory (adiponectin) markers. The gene discussed is TNF; the disease is obstructive sleep apnea syndrome.