Therefore, the aim of this study was to assess whether OSAHS is associated with activation of the inflammatory cytokine system in patients with ED compared to patients with OSAHS and normal sexual function, evaluating a wide range of inflammatory (hsCRP, IL-6, IL-8, and TNF-a) and anti-inflammatory (adiponectin) markers. This evidence concerns the gene IL6 and obstructive sleep apnea syndrome.