Indeed, this type of adipose tissue is able to produce proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and it is responsible of the increase of obesity-related CVD risk factors such as dyslipidemia, insulin resistance, and hypertension [31–33]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.