The CXCL12/CXCR4 axis delivers surviving signals to hepatocellular carcinoma cells, ovarian carcinoma cells, and chronic leukemia cells, while CXCR4 blockade induces the apoptosis of these malignant cells [38, 61, 75] (Figure 5). This evidence concerns the gene CXCR4 and hepatocellular carcinoma.