Overexpression of Brachyury causes EMT in human pancreatic cancer cell lines, along with enhanced expression of CXCL8, CCL5, and CXCL1, while the inhibition of CXCL8 signaling pathway abrogates Brachyury-induced EMT phenotypes and invasive capacity of cells [63]. The gene discussed is CXCL8; the disease is familial pancreatic carcinoma.