BRCA1 and Friedreich ataxia: Cells derived from Fanconi anemia (FA) patients or BRCA1/2-associated tumors that lack the BRCA-FA pathway (BRCA-FA cells) are extremely sensitive to agents such as mitomycin C (MMC) that induce ICLs (Moldovan & D'Andrea, 2009; Muniandy et al, 2010).