APOE and atherosclerosis: Interestingly, the murine dataset derived from ApoE-/- aortas of old mice (Mm_Ao_78w_ApoE_vs_wt) displayed a very similar OR pattern to the human dataset across all subnetworks, with the exception of the Platelet Activation subnetwork, which indicates that largely similar biological pathways underlie atherosclerosis in both species (Figure 4).