ITGAM and neoplasm: Metronomic CPA increased tumor levels of CD11b, which marks bone marrow-derived innate immune cells, including monocytes/macrophages, dendritic cells and NK cells [47], but when co-expressed with a second marker, Gr1, identifies bone marrow MDSCs [35], which populate distant sites ahead of colonizing metastatic cells, creating conditions favorable for metastatic growth [48].