Since it has been reported that CAPE is an activator of the Nrf2-ARE signalling pathway in mammalian cells [13], [14], we proofed this by additional experiments using Hct116 human colon carcinoma cells: By analysis of the localisation of this transcription factor (western blot analysis of nuclear and cytosolic fractions), a concentration-dependent accumulation of Nrf2 was detected both in the nuclear and cytosolic fraction (fig. The gene discussed is SMC2; the disease is colon carcinoma.