However, the CADM1 shedding rates, calculated as αCTF/full-length CADM1, βCTF/full-length CADM1, and (αCTF + βCTF)/full-length CADM1, were higher in the T2DM group, and the differences were statistically significant (Fig. 1c). Here, CADM1 is linked to type 2 diabetes mellitus.