We believe that the HGF/LIF therapy approach could prove beneficial to many muscular dystrophies and conditions leading to muscular atrophy as long as the primary defect is not affecting the muscle regeneration, which we have demonstrated is the case in some patients with limb-girdle muscular dystrophy type 2A (calpainopathy) [35]. The gene discussed is HGF; the disease is autosomal recessive limb-girdle muscular dystrophy type 2A.