Our study indicates that, the HLA-A*68, HLA-B*51, and HLA-DRB1*15 alleles showed significant positive associations with HD and have had susceptibility effects on the disease, whereas HLA-A*03 and HLA-DRB1*07 alleles were more frequent in controls than HD patients (but they did not remain significant after correction). The gene discussed is HLA-DRB1; the disease is Huntington disease.